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KMID : 0369820090390030167
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Jorunal of Korean Pharmaceutical Sciences
2009 Volume.39 No. 3 p.167 ~ p.171
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Preparation of Highly Porous Poly(d,L-Lactic-co-glycolic acid) (PLGA) Microspheres
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Youn Yu-Seok
Park Hong-Il
Kim Hyun-Uk
Lee Kang-Choon
Lee Eun-Seong
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Abstract
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Poly(lactic-co-glycolic acid) (PLGA) microspheres have been a useful tool as a controlled drug delivery system for peptides and proteins. Recently, porous microspheres have gained great attention as inhalation drug delivery system due to their low aerodynamic densities. Here, we report highly porous PLGA microspheres, which were prepared by using a single o/w emulsification/solvent evaporation method. Two types of porogen, i.e., (i) extractable Pluronic F127 and (ii) gas foaming salt of ammonium bicarbonate, were used to induce pores on the surface of PLGA microspheres. The respective preparation conditions on dp/cp ratio and porogen concentration were determined by the previous preliminary experiments, and other preparation factors were further optimized on the basis of PLGA Mw and porogen type. The morphological features examined by scanning electron microscope (SEM) show these porous microspheres have highly porous surface structure with a diameter range of 20~30 μm. These highly porous PLGA microspheres, which have much lower density, would be a practical aerosol system for pulmonary drug delivery.
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KEYWORD
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Porous microspheres, PLGA, Porogen, Pluronic F127, Gas foaming salt
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